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Diana Romenskaja

Junior Researcher, Centre for Innovative Medicine, Lithuania
I have a bioengineering bachelor’s degree and medical biology master’s degree. Currently I am a junior researcher and a PhD student at Centre for Innovative Medicine. Since the beginning of my scientific journey, I have been working with microglial cells and extracellular vesicles isolated from oral mucosal stem cell supernatants. I focus on research of interplay between extracellular vesicles and autophagy, lipid raft formation processes in human microglial cells.

Novel insights into the molecular mechanisms underlying the effects of

​extracellular vesicles on human microglial cells 

Dysregulated microglial response is important for the development and propagation of neurological disorders and therefore targeting of neuroinflammatory microglia is considered as a novel therapeutic strategy. Extracellular vesicles (EVs) containing multiple proteins, RNAs, lipids and metabolites effectively suppress neuroinflammation and induce neuroprotective effects in different pathological conditions.  Nevertheless, the mechanisms by which EVs regulate microglial responses remain largely unexplored. During my talk I will present our recent data about the effects of EVs derived from human oral mucosa stem cells on the migration, phagocytic activity, autophagy and inflammatory response of human microglial cells. I will also show that EVs interfere with Toll-like receptor 4 signaling, promote lipid raft formation and initiate downstream signaling pathways through milk fat globule-epidermal growth factor VIII (MFG-E8) – αVβ3/αVβ5 integrin – dependent mechanisms.  

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​This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 857418.
  • Home
    • About us
    • Combivet Ethics Committee
    • Contact
  • Team
  • Research
    • ​Host-Pathogen Interactions and Disease Biomarkers Discovery >
      • Research project I
      • Research project II
    • Infertility and Subfertility >
      • Research project III
      • Research project IV
      • Research project V
    • ​Food, Feed & Health >
      • Research project VI
    • Non - Communicable Diseases and Cancer >
      • Research project VII
      • Research project VIII
  • Publications
  • NEWS & EVENTS
    • News
    • Seminars
    • Events >
      • Annual conference 2024
      • Research school 2024
      • Ethics debate 2023
      • Research school 2023
      • Annual conference 2023
      • Symposium 2023
      • Conference 2022
      • Summer School 2022
      • One Health Estonia 2022
      • CANLEISH/COMBIVET joint event 2022
  • University of Life Sciences
  • EUP AH&W