Infertility and Subfertility

Farm animals and human fertility rates are showing significantly deceasing trend and one third of pregnancy failures are accounted as idiopathic or with unknown aetiology.   Both male and female subfertility and infertility conditions are directly contributing to the decreasing fertility rates. Understanding the gamete, embryo and female reproductive tract early communications, deciphering the uterine infections /dysbiosis on embryo development and implantation and finding the novel candidates and pathways to modulate the both human and farm animal endometrium and embryo to improve pregnancy rates would shed lights on devising the tools and techniques to improve fertility rates.  Moreover, recently fertility and issues have been linked to environmental pollutants like endocrine disrupters making the issue more of a one or planetary health problem.  Understanding human fertility related conditions is quite challenging given the sampling difficulties, thus in vitro cell culture and in vivo animal based studies are often use as popular research tools.  Moreover, in recently past a plethora of growing evidences suggest the involvement of extracellular vesicles in gametes and embryo development, fertilization of gametes, early maternal and embryo cross talks and endometrial receptivity opening up novel avenues to treat some of the subfertility and infertility issues improving assisted reproductive outcomes of both farm animals and humans. Thus, under this research theme the COBOVET ERA chair is employing comparative biomedicine approach to understand issues related to farm /companion animals and human to gain deep understanding of the aetiologies related to infertility and subfertility issues aiming to improve assisted reproduction outcomes.   

• ​​RESEARCH PROJECT III
  Understanding infertility and subfertility in Human and Livestock; Possible impact of the extracellular vesicles through Toll-Like Receptors pathways in embryo-maternal cross-talk
• RESEARCH PROJECT IV
  Exploring novel markers of embryo quality; Elucidating the molecular mechanism of extracellular vesicles targeting embryo maternal communication
• RESEARCH PROJECT V
  Deciphering the voids in determining male infertility