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​Dovydas Gečys

Junior Researcher, Lithuanian University of Health Sciences, Kaunus, Lithuani
​Dovydas Gecys is a junior researcher and a PhD student at Lithuanian University of Health Sciences. Currently he is working in Extracellular Vesicle research area with a focus to functionalize EVs for targeted drug delivery to glioblastoma cells. Additionally, he is working with biomarker research, gene engineering and epigenetics.​

Internalization of rgd-extracellular vesicles in glioblastoma cells ​

GBM internalization efficacy of exosome-like particles modified with RGD peptide. ​Glioblastoma multiforme (GBM) is the most common malignant type of tumor in central nervous system with one of the worst survival rates in the world. Despite available surgical and chemo/radio therapy treatments, most of the patients pass away within the first year of treatment. Poor outcome is caused by invasiveness, fast tumor recurrence and limited chemotherapy options [1,2]. Extracellular vesicles, a natural vehicle of bioactive materials, possess several essential attributes for drug delivery: ability to cross blood-brain barrier, low immunogenicity, specificity to the recipient cells and ability to be loaded with exogenous cargo [3,4]. It has been established that GBM cells have increased expression of transmembrane receptors called integrins which recognize tripeptide Arg-Gly-Asp (RGD) sequence [5]. Present study aims to investigate.

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​This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 857418.
  • Home
    • About us
    • Combivet Ethics Committee
    • Contact
  • Team
  • Research
    • ​Host-Pathogen Interactions and Disease Biomarkers Discovery >
      • Research project I
      • Research project II
    • Infertility and Subfertility >
      • Research project III
      • Research project IV
      • Research project V
    • ​Food, Feed & Health >
      • Research project VI
    • Non - Communicable Diseases and Cancer >
      • Research project VII
      • Research project VIII
  • Publications
  • NEWS & EVENTS
    • News
    • Seminars
    • Events >
      • Annual conference 2024
      • Research school 2024
      • Ethics debate 2023
      • Research school 2023
      • Annual conference 2023
      • Symposium 2023
      • Conference 2022
      • Summer School 2022
      • One Health Estonia 2022
      • CANLEISH/COMBIVET joint event 2022
  • University of Life Sciences
  • EUP AH&W