Dovydas Gečys
Junior Researcher, Lithuanian University of Health Sciences, Kaunus, Lithuani
Dovydas Gecys is a junior researcher and a PhD student at Lithuanian University of Health Sciences. Currently he is working in Extracellular Vesicle research area with a focus to functionalize EVs for targeted drug delivery to glioblastoma cells. Additionally, he is working with biomarker research, gene engineering and epigenetics.
Internalization of rgd-extracellular vesicles in glioblastoma cells
GBM internalization efficacy of exosome-like particles modified with RGD peptide. Glioblastoma multiforme (GBM) is the most common malignant type of tumor in central nervous system with one of the worst survival rates in the world. Despite available surgical and chemo/radio therapy treatments, most of the patients pass away within the first year of treatment. Poor outcome is caused by invasiveness, fast tumor recurrence and limited chemotherapy options [1,2]. Extracellular vesicles, a natural vehicle of bioactive materials, possess several essential attributes for drug delivery: ability to cross blood-brain barrier, low immunogenicity, specificity to the recipient cells and ability to be loaded with exogenous cargo [3,4]. It has been established that GBM cells have increased expression of transmembrane receptors called integrins which recognize tripeptide Arg-Gly-Asp (RGD) sequence [5]. Present study aims to investigate.
