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Marca Wauben

Professor of Intercellular Communication, Faculty of Veterinary Medicine, University of Utrecht, Netherlands
Marca Wauben is Full Professor Cell Biology (Chair: Intercellular Communication) at the Department of Biomolecular Health Sciences, Faculty Veterinary medicine, Utrecht University, The Netherlands. She is a pioneer in EV research and an expert in deciphering the role of nano-sized cell-derived vesicles (EVs) in intercellular communication in biological systems with emphasis on immunomodulation. Her research group has unveiled novel aspects in EV biogenesis, regulation of EV release, specific targeting, and cargo incorporation (including RNA, proteins, metabolites and lipids). By combining multi-omics with functional cellular modulation, the concept of EV-mediated modulation via the convergence of different EV-cargoes on nodes of regulation in cellular signal transduction pathways has been postulated. Milk-EV oriented research led to the development of tailored protocols for milk storage and milk EV isolation. Furthermore, integrated multi-omics and functional analysis of milk EV-mediated effects on T cells and epithelial cells, unveiled EV-cargo-function relationships and cross-species communication. Besides investigating fundamental immunological and regenerative aspects of EV-mediated communication, her research group works on EV-based biomarker discovery, (therapeutic) EV applications and the development of (nano)technology to analyze EVs, e.g. the pioneering work on high resolution flow cytometry-based technologies enabling single EV-based analysis and sorting.
Wauben is author of > n=150 peer reviewed scientific publications on EVs and (Co-)recipient of multiple EV-based consortium research grants, e.g. FP7 EU COST Action Microvesicles and Exosomes in Health and Disease (2012, vice-chair), H2020-MSCA-ITN-2016 TRAIN-EV research & training Network (722148) (2017) and H2020-FETOPEN The EV Foundry (801367)(2018). She has been/and is involved in many national and global initiatives to build a scientific community centered around EV-biology; e.g. the founding of the International Society for Extracellular Vesicles (ISEV), the scientific journal “Journal of Extracellular Vesicles”, the founding of the ISEV-ISAC-ISTH EV flowcytometry working group (www.evflowcytometry.org) and the founding of the Netherlands Society for Extracellular Vesicles (NLSEV) in 2018 (founding President). She is co-chair of the ISEV Milk EV Task Force and member of ISEV Regulatory affairs & clinical use of EV-based therapeutics Task Force. In 2019 she was awarded the ISEV special Achievement Award and in 2020 the ISEV life-time membership Award.

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​This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 857418.
  • Home
    • About us
    • Combivet Ethics Committee
    • Contact
  • Team
  • Research
    • ​Host-Pathogen Interactions and Disease Biomarkers Discovery >
      • Research project I
      • Research project II
    • Infertility and Subfertility >
      • Research project III
      • Research project IV
      • Research project V
    • ​Food, Feed & Health >
      • Research project VI
    • Non - Communicable Diseases and Cancer >
      • Research project VII
      • Research project VIII
  • Publications
  • NEWS & EVENTS
    • News
    • Seminars
    • Events >
      • Annual conference 2024
      • Research school 2024
      • Ethics debate 2023
      • Research school 2023
      • Annual conference 2023
      • Symposium 2023
      • Conference 2022
      • Summer School 2022
      • One Health Estonia 2022
      • CANLEISH/COMBIVET joint event 2022
  • University of Life Sciences
  • EUP AH&W